Donatello™ Series 3

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Donatello^® Series 3 Redefining Tissue Processing

Advanced innovation and technology in tissue processing

Your unique and unrepeatable sample deserves best-in-class safety.

Tissue processing is a one-way process where a number of chemicals steps and physical conditions will irreversibly determine the suitable processing of the specimen for the morphological (H&E), IHC and molecular analysis. Diagnostic-therapeutic algorithms for the selection of patients for targeted cancer treatment include immunohistochemical and molecular analysis of histological specimens. That’s why the quality of FFPE (Formalin Fixed Paraffin Embedded) specimens processed is mandatory.

Evolving Diagnostic and Therapeutic Scenario

Clinical care and Patient management

Pathology Diagnosis

Nucleic Acid (DNA, RNA) and protein expression

Target therapies to slow down or inhibit tumor’ growth

Why 3

Discover how Donatello^® Series 3 cutting-edge technology redefines tissue processing

1 IMMUNOTHERAPY

2 VALIDATED BIOMARKERS PROTOCOLS

3 SAFE DIAGNOSIS

Validated tissue processor for the preservation of immunohistochemical expression of PD- L1.The scientific publication demonstrates, in a comparative study, the interference of tissue processing in the evaluation of biomarkers useful in selecting patients who are candidates for immunotherapy.

The integrated protocols are validated by Diapath in collaboration with reference Hospitals, Laboratories and Reserch Institutes.These procedures are used daily for diagnostic purposes, immunohistochemistry, in-situ hybridisation and molecular biology investigations in order to identify predictive biomarkers of Immunotherapy response.

Donatello Series 3 is equipped with E.V.A. (Emergency eVoluted Alghorithm) designed for advanced safety.In the event of a mechanical blockage, especially during unmanned processing phases such as overnight processing, in case of critical situations and in the absence of an operator, is able to perform fully automatic troubleshooting operations, choosing the most appropriate corrective recovery action to save the samples.

DEMONSTRATING THE INTERFERENCE OF TISSUE PROCESSING IN THE EVALUATION OF TISSUE BIOMARKERS: THE CASE OF PD-L1

Ana Caramelo BSc¹, António Polónia MD, PhD^1,2, João Vale MSc¹, Mónica Curado BSc¹, Sofia Campelos MD¹, Vanessa Nascimento BSc¹, Mariana Barros BSc¹, Diana Ferreira BSc¹, Tânia Pereira BSc¹, Beatriz Neves BSc¹, Catarina Eloy MD PhD^1,2,3.

Pathology Laboratory, Institute of Molecular Pathology and Immunology of University of Porto (Ipatimup), Porto, Portugal.
Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal
Faculty of Medicine of University of Porto (FMUP), Porto, Portugal

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All information and data contained in this area, are to be considered private and confidential and is therefore prohibited the dissemination and publication of these data and information to third parties. You shall therefore keep confidential all information and data coming to its attention during the consultation, to keep them with security measures and a degree of care no less than those accorded to its own confidential information. Access to this area requires the full and complete acceptance of the conditions listed; Diapath therefore reserves the right to pursue all offenders under current regulations and to seek compensation for all damages suffered and patiendi.

The Donatello^® Series 3 is especially designed to preserve the integrity of proteins and nucleic acids in biological tissue samples suitable for diagnosis and evaluation of biomarkers predictive of therapy response.

Donatello^® Series 3,
technology features

E.V.A.+

SelfCheck+

RFID

BUBBLING

ABS

MAXIMUM PRODUCTIVITY

SECURITY SENSOR

ENERGY MONITORING SYSTEM

SAFE REAGENT

FPS

ID CARD

SENSOR LEVEL

The intelligent virtual algorithm is able, in case of a mechanical blockage, to perform operations in a totally automatic way aimed at solving problems without interrupting the processing.E.V.A.+ is also equipped with a voice- user interface making spoken human interaction easy.

The Self-diagnostic system prevents unexpected stops during overnight processing.The procedure is performed automatically before each processing, via automatic check on the sensitive mechanical parts of the processor.

Quick and safe identification of dedicated pre- filled containers. The software and LEDs guide the reagent replacement procedure, thus preventing any reagent refill errors.

Innovative reagent mixing technology.

The ABS system makes the instrument less susceptible to impurities, such as the incidental presence of organic(release of tissue components during processing), inorganic substances and foreign bodies (dirt, dye powder residues that may accidentally circulate inside the instrument).Insoluble fragments circulating within any hydraulic system may cause blockage phenomena of an embolic- like nature. ABS also contributes to the reduction of cross-contamination between reagents by extending the shelf - life of process reagents.

Thanks to its large processing chamber and its reagent mixing technology, Donatello is able to process up to 420 standard biocassettes, up to 112 Slim Mega Cassettes and up to 56 Super Mega Cassettes(with dedicated basket) with a single run.

Able to track incidental removal of reagent tanks via sensor(Date, Time, and Operator).

Donatello Series 3 is equipped with a system that can perform real- time monitoring of the instrument’s energy consumption, maximizing the energy efficiency of the instrument and increasing overall performance.

<body><span class="tab-title">SAFE REAGENT</span><br></body>Donatello Series 3 offers the possibility to set a custom safety reagent for each step of the processing. In the event of a power failure, a Safe Reagent will be loaded into the processing chamber to keep the samples safe until Laboratory staff arrives(only with UPS connection).The Safe Reagent will also intervene downstream of the various attempts of the emergency procedure carried out by E.V.A.+

Ideal for preheating of the reagent in a safe and homogeneous way before its actual use inside the processing chamber.This technology allows for the processing of small biopsies(up to 1 mm thickness) in less than an hour.The FPS is activated only whenthe reagent passes through preventing power consumption.

RFID-technology-based ID card, makes user login, reagent’ and lot expiry’ traceability easy and intuitive.

For real time fluodinamic monitoring and detect the presence of the reagent and the correct fill level to prevent samples from drying out.

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Donatello^® Series 3, overview

ALL-IN-ONE PC

SPC

SPC LOCK SYSTEM

3 CYLINDERS FOR PARAFFINS

EWD RFILL RDRAIN CONNECTORS

SECURITY SENSOR

ACTIVE LED SYSTEM

RFID TECHNOLOGY

USB PORT

PWD TANK

12 TANKS FOR REAGENTS

WHEELS FOR EASY MOVING

With 15” color touchscreen.

In stainless steel, resistant to solvents and heat. 4 capacitive and adaptive level sensors that can detect the presence of the reagent and the correct filling level.

Totally controlled by software. Equipped with a system that can detect incorrect process chamber closure and alert the operator in 4 seconds.

With a capacity of 4.7 (max) and 4.4 (min) liters each.

For external paraffin unloading and for remote loading/ unloading of reagents.

Able to track possible removal of reagent tanks via sensor.

Dynamic LED for each reagent station to guide the operator during the replacement of the tanks and view the status of the instrument and the reagents.

Housing for pre-filled tank for a quick and safe identifcation of reagents and rapid user login.

Easily accessible for exporting the data contained in the instrument database.

For the internal discharge of the exhausted paraffin in a dedicated tank.

9 dedicated to processing reagents, 2 dedicated to washing reagents and 1 PWD tank(5 liters each).

With locking lever.

DEMONSTRATING THE INTERFERENCE OF TISSUE PROCESSING IN THE EVALUATION OF TISSUE BIOMARKERS: THE CASE OF PD-L1

The results of this study suggest that, analytic conditions less often motive of consideration such as tissue processing, may be major culprits in the lack of consistent results of biomarkers evaluation, such as PD-L1. […]

These observations support others reported in the literature that support the urgent need to standardize tissue processing and to review the basic chemistry associated with the biomarkers evaluation, since it has been proved to fail as a solid quantitative method. […]

This study demonstrates the need to review and standardize the tissue processing in pathology laboratories to cope with the growing needs of precision medicine inherent quantifications and the production of high quality material necessary for computational pathology usage.

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Donatello is safety
for your health.

GREEN SOLUTION - OTTIX

Ottix is Diapath’s patented solution consisting of two reagents replacing the complete alcohol scale and xylene. Through the application of protocols validated and used all over the World for more than ten years, Ottix guarantees better results than traditional reagents, especially when used for processing breast, skin and fatty tissue samples.

ACTIVATED CARBON FILTERS

Donatello^® Series 3 has two high performance activated carbon filters for the removal of compound hydrocarbons. The instrument has a suction point, with a dedicated filter, above the processing chamber.

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Flexibility
for your routine

MAXIMUM PRODUCTIVITY

Donatello, thanks to its large processing chamber and its reagent mixing technology, allows to process up to 420 standard biocassettes with a single processing. With the dedicated basket, it is then possible to process up to 112 Slim Mega Cassettes and up to 56 Super Mega Cassettes with a single processing.

FPS - FAST PROCESSING

The FPS (Fast Processing System) is a system that allows the preheating of the reagent in a safe and homogeneous way before its actual use inside the processing chamber. The use of this technology allows for the processing of small biopsies (up to 1 mm thickness) in less than an hour.

Diapath
Italian Iconic Design

Diapath Donatello Series Automatic Tissue Processor is Silver Winner of A’Design Award and Competition in Scientific Instruments, Medical Devices and Research Equipment Design Category.

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Remote Assistance Plus

Our solution for overall business continuity. Communicate with Diapath experts. A simple web connection is enough.

Speed in solving problems
Specialized and tailor-made assistance for you
Guaranteed competence

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Optional accessories

FOR THE COMPLETE LIST, CHECK THE TECHNICAL SHEET

SDSPA9066	Basket for Super Mega Cassettes
CRDEA903-IIIPRO	UPS
SDSBR0001	Barcode reader cordless for Donatello^® Series
CRD-RT01N	Router for Remote Assistance
SDSAD0001	Auto dialer 115-230 V
SDSPA9069	Support for pipes
SDXCE9005	ID card USER, RFID-technology-based, 5 pcs
SDSPA9060	Tray for basket